Board certification
American Osteopathic Board of Surgery, 2007

Founder, Medical Director, Physician, Surgeon
Dr. Mark Khorsandi, an esteemed provider of BOTOX® for migraines in Houston, is a highly trained and experienced physician and surgeon. He holds a Bachelor's degree from Boston College and a Doctor of Osteopathic Medicine degree from Nova Southeastern University. His experience spans prestigious hospitals in New York, including Peninsula Hospital Center, Memorial Sloan-Kettering, Westchester Medical Center, Albert Einstein, Beth Israel, and LIJ Consortium.
Under the mentorship of sports-related hand-injury surgeon Dr. Charles P. Melone, Dr. Khorsandi completed a specialized fellowship. As a result, he stands out as one of the few surgeons in Texas trained in migraine, hand, and micro-surgery. His practice specializes in peripheral nerve surgery, neuropathy treatment, and migraine relief using effective methods like BOTOX®.
In addition to being a dedicated provider of Houston BOTOX® migraine solutions, Dr. Khorsandi offers a wide range of skincare and aesthetic services tailored to each patient's unique needs and concerns. Whether you are looking to improve the appearance of fine lines and wrinkles, address sun damage, or enhance overall skin health, Dr. Khorsandi brings the expertise and experience to help guide your goals.
Recognized for his contributions to BOTOX® for migraines in Houston, Dr. Khorsandi is the founder of ZO Skin Centre Houston and the Migraine Relief Center in Houston. He also holds part ownership of ZO Skin Centre Dallas. His passion for skincare and aesthetics is reflected in his rigorous education and comprehensive training.
Under the direct mentorship of Dr. Zein Obagi, a celebrated pioneer in skincare known for the ZO Skin Health line, Dr. Khorsandi has significantly honed his aesthetic skills. This learning experience included multiple visits to Dr. Obagi's Beverly Hills clinic. Dr. Khorsandi also regularly participates in laser and aesthetics courses to stay current with industry advancements.
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The Texas Medical Board lists Dr. Mark Darius Khorsandi, DO, as an actively licensed Texas physician with no disciplinary or non-disciplinary restrictions.
Information current as of September 10, 2026.
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These details appear on the physician profile but may not have been independently verified by the Texas Medical Board.
American Osteopathic Board of Surgery, 2007
Primary: hand surgery. Secondary: general surgery.
General surgery internship at Philadelphia College of Osteopathic Medicine, 1999–2000; general surgery residency at Peninsula Hospital Center, 2000–2004.
Memorial Hermann Northwest Surgery Center; Memorial Hermann Memorial City; Altus in Baytown; River Oaks at Oak Bend; and Townsen Memorial Hospital.
22 years of active practice in the U.S. or Canada, including 15 years in Texas.
No reportable malpractice claims, self-reported criminal offenses, or non-TMB disciplinary actions listed.
A look at the physician-led care philosophy behind ZO Skin Centre Houston.
Book with Dr. Mark Khorsandi